The science: Over-the-counter oral antihistamine can soothe a rash that is swollen, red or itchy. Oral antihistamines are a good way to treat rashes because they work on the immune system and help to regulate the response to an allergen. They work systemically to soothe symptoms, Soliman says.
The catch: Same as before, be cautious of interference with other medication and note that some antihistamines can cause drowsiness.
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