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So far, the evidence is statistical. That is, researchers have not established a direct cause-and-effect relationship. But a study by Dr. Ralph Paffenbarger, Jr., at the University of California School of Public Health showed that former male college students who- reported drinking coffee daily had 1.4 times the risk of developing peptic ulcers that noncoffee-drinkers did. If gastric acid secretion is the culprit, then decaffeinated coffee is no improvement on regular coffee”, since it is every bit as potent a stimulator.
Caffeine has also been suspected of contributing to birth defects. Once again, the evidence is anything but conclusive. Still, many physicians are advising mothers-to-be to avoid caffeine-containing beverages while pregnant. Caffeine is so configurated, molecularly, that it can cross the placenta and enter the fetal gonad. At the very least, according to Dr. John J. Mulvihill, head of clinical genetics in the National Cancer Institute epidemiology branch, caffeine is highly mutagenic and possibly even teratogenic. This would imply that caffeine might cause chromosomal changes and abnormal babies.
QUESTIONS AND ANSWERS
Is decaffeinated coffee safe?

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